Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint.

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第一作者： Hsiao-Wei,Tsao

第一单位： Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.

作者： Hsiao-Wei,Tsao ^[1] ; Seth,Anderson ^[1] ; Kenneth J,Finn ^[2] ; Jonathan J,Perera ^[1] ; Lomax F,Pass ^[1] ; Emily M,Schneider ^[1] ; Aiping,Jiang ^[1] ; Rachel,Fetterman ^[1] ; Cun Lan,Chuong ^[1] ; Kaiya,Kozuma ^[1] ; Marcia M,Stickler ^[2] ; Marc,Creixell ^[2] ; Susan,Klaeger ^[3] ; Kshiti Meera,Phulphagar ^[3] ; Suzanna,Rachimi ^[3] ; Eva K,Verzani ^[3] ; Niclas,Olsson ^[2] ; Juan,Dubrot ^[1] ; Matthew F,Pech ^[2] ; Whitney,Silkworth ^[2] ; Sarah Kate,Lane-Reticker ^[1] ; Peter M,Allen ^[1] ; Kyrellos,Ibrahim ^[1] ; Nelson H,Knudsen ^[1] ; Andrew Y,Cheng ^[1] ; Adrienne H,Long ^[4] ; Hakimeh,Ebrahimi-Nik ^[1] ; Sarah Y,Kim ^[1] ; Peter P,Du ^[1] ; Arvin,Iracheta-Vellve ^[1] ; Emily J,Robitschek ^[1] ; Juliette S M T,Suermondt ^[1] ; Thomas G R,Davis ^[1] ; Clara H,Wolfe ^[1] ; Trisha,Atluri ^[1] ; Kira E,Olander ^[1] ; Jason S,Rush ^[3] ; Thomas B,Sundberg ^[3] ; Fiona E,McAllister ^[2] ; Jennifer G,Abelin ^[3] ; Ari,Firestone ^[2] ; David,Stokoe ^[2] ; Steven A,Carr ^[3] ; Fiona A,Harding ^[5] ; Kathleen B,Yates ^[6] ; Robert T,Manguso ^[7]

作者单位： Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. ^[1] Calico Life Sciences, South San Francisco, CA, USA. ^[2] Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. ^[3] Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ^[4] Calico Life Sciences, South San Francisco, CA, USA. Electronic address: fah@calicolabs.com. ^[5] Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address: yates@broadinstitute.org. ^[6] Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address: rmanguso@broadinstitute.org. ^[7]

关键词 ERAP HLA-E NKG2A Qa-1b Qdm VL9 antigen presentation checkpoint blockade immunotherapy peptide loading complex