首页> Developmental cell> Initiation and maintenance of the pluripotent epiblast in pre-implantation human development is independent of NODAL signaling.

Initiation and maintenance of the pluripotent epiblast in pre-implantation human development is independent of NODAL signaling.

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第一作者： A Sophie,Brumm

第一单位： Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

作者： A Sophie,Brumm ^[1] ; Afshan,McCarthy ^[1] ; Claudia,Gerri ^[1] ; Todd,Fallesen ^[2] ; Laura,Woods ^[3] ; Riley,McMahon ^[3] ; Athanasios,Papathanasiou ^[4] ; Kay,Elder ^[4] ; Phil,Snell ^[4] ; Leila,Christie ^[4] ; Patricia,Garcia ^[5] ; Valerie,Shaikly ^[5] ; Mohamed,Taranissi ^[5] ; Paul,Serhal ^[6] ; Rabi A,Odia ^[6] ; Mina,Vasilic ^[6] ; Anna,Osnato ^[7] ; Peter J,Rugg-Gunn ^[8] ; Ludovic,Vallier ^[9] ; Caroline S,Hill ^[10] ; Kathy K,Niakan ^[11]

作者单位： Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, London NW1 1AT, UK. ^[1] Crick Advanced Light Microscopy, The Francis Crick Institute, London NW1 1AT, UK. ^[2] Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK. ^[3] Bourn Hall Clinic, Bourn, Cambridge CB23 2TN, UK. ^[4] Assisted Reproduction and Gynaecology Centre, London W1G 6LP, UK. ^[5] Centre for Reproductive and Genetic Health, London W1W 5QS, UK. ^[6] Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK; Department of Development and Regeneration, University of Leuven, Leuven 3000, Belgium. ^[7] Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK. ^[8] Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK. ^[9] Developmental Signalling Laboratory, The Francis Crick Institute, London NW1 1AT, UK. ^[10] Human Embryo and Stem Cell Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Loke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK; Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK. Electronic address: kkn21@cam.ac.uk. ^[11]

关键词 BMP signaling NANOG NODAL signaling epiblast human embryo pluripotency