<i>KCTD10</i> p.C124W variant contributes to schizophrenia by attenuating LLPS-mediated synapse formation.

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第一作者： Chenjun,Mu

第一单位： Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.

作者： Chenjun,Mu ^[1] ; Pan,Liu ^[1] ; Liang,Liu ^[2] ; Yaqing,Wang ^[3] ; Kefu,Liu ^[1] ; Xiangyu,Li ^[1] ; Guozhong,Li ^[1] ; Jianbo,Cheng ^[1] ; Mengyao,Bu ^[1] ; Han,Chen ^[1] ; Manpei,Tang ^[1] ; Yuanhang,Yao ^[4] ; Jun,Guan ^[1] ; Tiantian,Ma ^[3] ; Zhengrong,Zhou ^[5] ; Qingfeng,Wu ^[3] ; Jiada,Li ^[6] ; Hui,Guo ^[6] ; Kun,Xia ^[6] ; Zhengmao,Hu ^[6] ; Xiaoqing,Peng ^[6] ; Bing,Lang ^[7] ; Faxiang,Li ^[6] ; Xiao-Wei,Chen ^[4] ; Zhiheng,Xu ^[3] ; Ling,Yuan ^[6]

作者单位： Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China. ^[1] Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. ^[2] State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100101, China. ^[3] Center for Life Sciences, Institute of Molecular Medicine, School of Future Technology, Peking University, Beijing 100871, China. ^[4] Department of Basic Medical Sciences, Neuroscience Center, Shantou University Medical College, Shantou, Guangdong 515041, China. ^[5] Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Science, Central South University, Changsha, Hunan 410078, China.;Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Science, Central South University, Changsha, Hunan 410078, China. ^[6] Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. ^[7]

关键词 KCTD10 liquid–liquid phase separation (LLPS)neuropsychiatric disorder synaptic abnormalities

主题词动物(Animals);精神分裂症(Schizophrenia);小鼠(Mice);突触(Synapses);人类(Humans);突变(Mutation);钾通道, 电压门控(Potassium Channels, Voltage-Gated)

DOI 10.1073/pnas.2400464121

PMID 39565307

发布时间 2024-12-07

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