Optimizing the procedure for manufacturing clinical-grade genetically manipulated natural killer cells for adoptive immunotherapy.

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作者： Haolong,Lin ^[1] ; Shanwei,Ye ^[2] ; Shujia,Zhang ^[2] ; Tong,Ge ^[2] ; Dengju,Li ^[2] ; Liang,Huang ^[3] ; Li,Zhu ^[4] ; Wei,Mu ^[5]

作者单位： Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, Hubei, China; Key Laboratory of Hematology, Guangxi Medical University, Education Department of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. ^[1] Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, Hubei, China. ^[2] Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, Hubei, China; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China; Tianjin Institutes of Health Science, Tianjin, China. ^[3] Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, Hubei, China. Electronic address: judy831109@tjh.tjmu.edu.cn. ^[4] Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, Hubei, China. Electronic address: muweicelltherapy@163.com. ^[5]

关键词 CAR-NK cells Clinical-grade manufacturing Ex vivo expansion Genetic manipulation NK cell immunotherapy

主题词杀伤细胞, 天然(Killer Cells, Natural);人类(Humans);免疫疗法, 过继(Immunotherapy, Adoptive);细胞毒性, 免疫(Cytotoxicity, Immunologic);动物(Animals)

DOI 10.1016/j.jcyt.2024.10.006

PMID 39570247

发布时间 2025-01-13

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