A multifaceted approach to understanding protein-buffer interactions in biopharmaceuticals.

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作者： Blaž,Lebar ^[1] ; Maria,Orehova ^[2] ; Boštjan,Japelj ^[3] ; Ernest,Šprager ^[3] ; Rok,Podlipec ^[4] ; Tilen,Knaflič ^[4] ; Iztok,Urbančič ^[4] ; Benjamin,Knez ^[3] ; Mitja,Zidar ^[3] ; Jure,Cerar ^[3] ; Janez,Mravljak ^[5] ; Aleš,Žula ^[3] ; Denis,Arčon ^[4] ; Janez,Plavec ^[2] ; Stane,Pajk ^[6]

作者单位： University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Aškerčeva 7, SI-1000 Ljubljana, Slovenia; Novartis Pharmaceutical Manufacturing LLC, Kolodvorska 27, SI-1234 Menges, Slovenia. ^[1] National Institute of Chemistry, Slovenian NMR Centre, Hajdrihova ulica 19, SI-1000 Ljubljana, Slovenia. ^[2] Novartis Pharmaceutical Manufacturing LLC, Kolodvorska 27, SI-1234 Menges, Slovenia. ^[3] Jožef Stefan Institute, Laboratory of Biophysics & Quantum Materials Group, Jamova cesta 39, SI-1000 Ljubljana, Slovenia. ^[4] University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Aškerčeva 7, SI-1000 Ljubljana, Slovenia. ^[5] University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Aškerčeva 7, SI-1000 Ljubljana, Slovenia. Electronic address: stane.pajk@ffa.uni-lj.si. ^[6]

关键词 Buffer Interaction Methyl fingerprinting Molecular dynamics Monoclonal antibody Nuclear magnetic resonance