MAGE-A4 pMHC-targeted CAR-T cells exploiting TCR machinery exhibit significantly improved in vivo function while retaining antigen specificity.

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作者： Meiou,Liu ^[1] ; Yasushi,Akahori ^[1] ; Naoko,Imai ^[1] ; Linan,Wang ^[2] ; Kohei,Negishi ^[1] ; Takuma,Kato ^[3] ; Hiroshi,Fujiwara ^[1] ; Hiroshi,Miwa ^[1] ; Hiroshi,Shiku ^[1] ; Yoshihiro,Miyahara ^[4]

作者单位： Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Japan. ^[1] Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Japan. ^[2] Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan. ^[3] Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Japan miyahr-y@med.mie-u.ac.jp. ^[4]

关键词 Adoptive cell therapy - ACT Chimeric antigen receptor - CAR Major histocompatibility complex - MHC Solid tumor T cell Receptor - TCR

主题词人类(Humans);抗原, 肿瘤(Antigens, Neoplasm);小鼠(Mice);动物(Animals);免疫疗法, 过继(Immunotherapy, Adoptive);肿瘤蛋白质类(Neoplasm Proteins);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);细胞系, 肿瘤(Cell Line, Tumor);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);肿瘤(Neoplasms);主要组织相容性复合物(Major Histocompatibility Complex)

DOI 10.1136/jitc-2024-010248

PMID 39572159

发布时间 2024-11-23

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Journal for immunotherapy of cancer

2024年12卷11期

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MAGE-A4 pMHC-targeted CAR-T cells exploiting TCR machinery exhibit significantly improved in vivo function while retaining antigen specificity.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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MAGE-A4 pMHC-targeted CAR-T cells exploiting TCR machinery exhibit significantly improved in vivo function while retaining antigen specificity.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

相关期刊

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