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Plasma pTau217 ratio predicts continuous regional brain tau accumulation in amyloid-positive early Alzheimer's disease.

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第一作者： Viswanath,Devanarayan

第一单位： Clinical Evidence Generation, Eisai Inc., Nutley, New Jersey, USA.;Department of Mathematics, Statistics and Computer Science, University of Illinois Chicago, Chicago, Illinois, USA.

作者： Viswanath,Devanarayan ^[1] ; Arnaud,Charil ^[2] ; Kanta,Horie ^[3] ; Thomas,Doherty ^[4] ; Daniel A,Llano ^[5] ; Erica,Andreozzi ^[2] ; Pallavi,Sachdev ^[2] ; Yuanqing,Ye ^[2] ; Leema Krishna,Murali ^[2] ; Jin,Zhou ^[2] ; Larisa,Reyderman ^[2] ; Harald,Hampel ^[2] ; Lynn D,Kramer ^[2] ; Shobha,Dhadda ^[2] ; Michael C,Irizarry ^[2] ; Alzheimer's Disease Neuroimaging Initiative (ADNI)

作者单位： Clinical Evidence Generation, Eisai Inc., Nutley, New Jersey, USA.;Department of Mathematics, Statistics and Computer Science, University of Illinois Chicago, Chicago, Illinois, USA. ^[1] Clinical Evidence Generation, Eisai Inc., Nutley, New Jersey, USA. ^[2] Clinical Evidence Generation, Eisai Inc., Nutley, New Jersey, USA.;The Tracy Family SILQ Center, Washington University School of Medicine, St Louis, Missouri, USA.;Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA. ^[3] Clinical Evidence Generation, Eisai Ltd., Hatfield, UK. ^[4] Biomedical and Translational Sciences, Carle Illinois College of Medicine, Urbana, Illinois, USA.;Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.;Intelligent Systems, Beckman Institute for Advanced Science and Technology, Urbana, Illinois, USA. ^[5]

关键词 Tau PET blood–based biomarkers diagnosis disease continuum disease staging patient monitoring patient screening prediction