T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type 1 cells.

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作者： Josep,Garnica ^[1] ; Patricia,Sole ^[1] ; Jun,Yamanouchi ^[2] ; Joel,Moro ^[1] ; Debajyoti,Mondal ^[2] ; Cesar,Fandos ^[1] ; Pau,Serra ^[1] ; Pere,Santamaria ^[3]

作者单位： Institut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. ^[1] Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. ^[2] Institut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.;Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. ^[3]

关键词 T-follicular helper cells T-regulatory type 1 cells TFH cells TR1 cells epigenetics immunology immunoregulation inflammation mouse pMHCII-based nanomedicines peptide-major histocompatibility complex class II - based nanomedicines transdifferentiation

主题词动物(Animals);细胞转分化(Cell Transdifferentiation);后成说, 遗传(Epigenesis, Genetic);小鼠(Mice);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);小鼠, 近交C57BL(Mice, Inbred C57BL);T淋巴细胞, 辅助诱导(T-Lymphocytes, Helper-Inducer)

DOI 10.7554/eLife.97665

PMID 39576679

发布时间 2024-11-24

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