Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem.

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作者： Sila,Ataca ^[1] ; Maya,Sangesland ^[2] ; Rebeca,de Paiva Fróes Rocha ^[3] ; Alba,Torrents de la Peña ^[3] ; Larance,Ronsard ^[2] ; Seyhan,Boyoglu-Barnum ^[1] ; Rebecca A,Gillespie ^[1] ; Yaroslav,Tsybovsky ^[4] ; Tyler,Stephens ^[4] ; Syed M,Moin ^[1] ; Julia,Lederhofer ^[1] ; Adrian,Creanga ^[1] ; Sarah F,Andrews ^[1] ; Ralston M,Barnes ^[5] ; Daniel,Rohrer ^[5] ; Nils,Lonberg ^[5] ; Barney S,Graham ^[1] ; Andrew B,Ward ^[3] ; Daniel,Lingwood ^[2] ; Masaru,Kanekiyo ^[6]

作者单位： Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ^[1] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. ^[2] The Scripps Research Institute, La Jolla, CA 92037, USA. ^[3] Vaccine Research Center Electron Microscopy Unit, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 20701, USA. ^[4] Bristol-Myers Squibb, Redwood City, CA 94063, USA. ^[5] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: kanekiyom@nih.gov. ^[6]

关键词 B cell CP: Immunology HA stem IGHD3-9 IGHV1-69 bnAb broadly neutralizing antibody germline-targeting hemagglutinin influenza virus nanoparticle