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Stiffening symphony of aging: Biophysical changes in senescent osteocytes.

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第一作者： Maryam,Tilton

第一单位： Walker Department of Mechanical Engineering, The University of Texas at Austin, Austin, Texas, USA.

作者： Maryam,Tilton ^[1] ; Megan,Weivoda ^[2] ; Maria,Astudillo Potes ^[3] ; Anne,Gingery ^[4] ; Alan Y,Liu ^[5] ; Tamara,Tchkonia ^[6] ; Lichun,Lu ^[3] ; James L,Kirkland ^[6]

作者单位： Walker Department of Mechanical Engineering, The University of Texas at Austin, Austin, Texas, USA. ^[1] Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.;Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA. ^[2] Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.;Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA. ^[3] Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.;Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.;Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA. ^[4] Optics11 Life Inc., Boston, Massachusetts, USA. ^[5] Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.;Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. ^[6]

关键词 cellular senescence cytoskeleton mechanics osteocyte mechanobiology sub cellular structure

医学主题词骨细胞(Osteocytes);动物(Animals);小鼠(Mice);衰老(Aging);动力传导, 细胞(Mechanotransduction, Cellular);细胞骨架(Cytoskeleton)

DOI 10.1111/acel.14421

PMID 39582140

发布时间 2026-03-25

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