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Childhood, adolescent, and young adulthood cancer risk in BRCA1 or BRCA2 pathogenic variant carriers.

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第一作者： Shuai,Li

第一单位： Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia.;Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia.;Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom.

作者： Shuai,Li ^[1] ; Laura,Madanat-Harjuoja ^[2] ; Goska,Leslie ^[3] ; Daniel R,Barnes ^[3] ; Manjeet K,Bolla ^[3] ; Joe,Dennis ^[3] ; Michael T,Parsons ^[4] ; Paraskevi,Apostolou ^[5] ; Norbert,Arnold ^[6] ; Kristin,Bosse ^[7] ; EMBRACE Collaborators ^[8] ; Jackie,Cook ^[9] ; Christoph,Engel ^[10] ; D Gareth,Evans ^[5] ; Florentia,Fostira ^[11] ; Megan N,Frone ^[12] ; Andrea,Gehrig ^[11] ; Mark H,Greene ^[13] ; Karl,Hackmann ^[14] ; Eric,Hahnen ^[15] ; Nadia,Harbeck ^[16] ; Jan,Hauke ^[17] ; Julia,Hentschel ^[18] ; Judit,Horvath ^[19] ; Louise,Izatt ^[20] ; Marion,Kiechle ^[5] ; Irene,Konstantopoulou ^[21] ; Fiona,Lalloo ^[22] ; Joanne,Ngeow ^[23] ; Dieter,Niederacher ^[24] ; Julia,Ritter ^[25] ; Marta,Santamariña ^[16] ; Rita K,Schmutzler ^[26] ; Claire,Searle ^[27] ; Christian,Sutter ^[28] ; Marc,Tischkowitz ^[19] ; Vishakha,Tripathi ^[25] ; Ana,Vega ^[29] ; Hannah,Wallaschek ^[30] ; Shan,Wang-Gohrke ^[14] ; Barbara,Wappenschmidt ^[31] ; Bernhard H F,Weber ^[5] ; Drakoulis,Yannoukakos ^[3] ; Emily,Zhao ^[32] ; Douglas F,Easton ^[3] ; Antonis C,Antoniou ^[33] ; Georgia,Chenevix-Trench ^[34] ; Timothy R,Rebbeck ^[35] ; Lisa R,Diller

作者单位： Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia.;Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia.;Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom. ^[1] Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki 00029, Finland.;Finnish Cancer Registry, Helsinki 00130, Finland. ^[2] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom. ^[3] Public Health Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia. ^[4] Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens 15310, Greece. ^[5] Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Christian-Albrechts University Kiel, Campus Kiel, Kiel 24105, Germany.;Institute of Clinical Molecular Biology, University Hospital of Schleswig-Holstein, Christian-Albrechts University Kiel, Campus Kiel, Kiel 24118, Germany. ^[6] Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen 72074, Germany. ^[7] Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield S10 2TH, United Kingdom. ^[8] Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig 04107, Germany.;LIFE-Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig 04103, Germany. ^[9] Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom.;North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom. ^[10] Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20850-9772, United States. ^[11] Department of Human Genetics, University Würzburg, Würzburg 97074, Germany. ^[12] Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, Dresden, Dresden, TU 01307, Germany. ^[13] Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne 50937, Germany.;Center for Integrated Oncology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne 50937, Germany. ^[14] Department of Gynecology and Obstetrics, University of Munich, Campus Großhadern, Munich 81377, Germany. ^[15] Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne 50937, Germany.;Center for Integrated Oncology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne 50937, Germany.;Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne 50931, Germany. ^[16] Institute of Human Genetics, University Hospital Leipzig, Leipzig 04103, Germany. ^[17] Institute of Human Genetics, University of Münster, Münster 48149, Germany. ^[18] Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK. ^[19] Department of Gynaecology and Obstetrics, University Hospital Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich 80333, Germany. ^[20] Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust, Manchester M13 9WL, United Kingdom. ^[21] Lee Kong Chian School of Medicine, Nanyang Technological University, 308232, Singapore.;Cancer Genetics Service, National Cancer Centre, 169610, Singapore. ^[22] Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf 40225, Germany. ^[23] Institute of Medical and Human Genetics, Charité -Universitätsmedizin Berlin, Berlin 13353, Germany. ^[24] Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid 28029, Spain.;Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela 15706, Spain.;Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela 15706, Spain. ^[25] Department of Clinical Genetics, Nottingham University Hospitals NHS Trust, Nottingham NG5 1PB, United Kingdom. ^[26] Institute of Human Genetics, University Hospital Heidelberg, Heidelberg 69120, Germany. ^[27] Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.;Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC H4A 3J1, Canada. ^[28] Institute of Human Genetics, Hannover Medical School, Hannover 30625, Germany. ^[29] Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm 89075, Germany. ^[30] Institute of Human Genetics, University Regensburg, Regensburg 93053, Germany.;Institute of Clinical Human Genetics, University Hospital Regensburg, Regensburg 93053, Germany. ^[31] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, United Kingdom.;Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, United Kingdom. ^[32] Cancer Research Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia. ^[33] Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States.;Dana-Farber Cancer Institute, Boston, MA 02115, United States. ^[34] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, United States.;Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States. ^[35]