RNA N<sup>6</sup>-Methyladenosine-Binding Protein YTHDFs Redundantly Attenuate Cancer Immunity by Downregulating IFN-γ Signaling in Gastric Cancer.

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作者： Dongjun,Jang ^[1] ; Chanwoong,Hwa ^[2] ; Seoyeon,Kim ^[2] ; Jaeik,Oh ^[3] ; Seungjae,Shin ^[1] ; Soo-Jin,Lee ^[1] ; Jiwon,Kim ^[1] ; Sang Eun,Lee ^[1] ; Yoojin,Yang ^[1] ; Dohee,Kim ^[1] ; Seoho,Lee ^[1] ; Hae Rim,Jung ^[4] ; Yumi,Oh ^[4] ; Kyunggon,Kim ^[5] ; Hye Seung,Lee ^[6] ; Joon-Yong,An ^[7] ; Sung-Yup,Cho ^[8]

作者单位： Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, South Korea. ^[1] L-HOPE Program for Community-Based Total Learning Health Systems, Korea University, Seoul, 02841, South Korea.;Department of Integrated Biomedical and Life Science, Korea University, Seoul, 02841, South Korea. ^[2] Department of Translational Medicine, Seoul National University College of Medicine, Seoul, 03080, South Korea. ^[3] Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, 03080, South Korea. ^[4] Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, 05505, South Korea. ^[5] Department of Pathology, Seoul National University College of Medicine, Seoul, 03080, South Korea.;Cancer Research Institute, Seoul National University, Seoul, 03080, South Korea. ^[6] L-HOPE Program for Community-Based Total Learning Health Systems, Korea University, Seoul, 02841, South Korea.;Department of Integrated Biomedical and Life Science, Korea University, Seoul, 02841, South Korea.;School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, 02841, South Korea. ^[7] Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, South Korea.;Department of Translational Medicine, Seoul National University College of Medicine, Seoul, 03080, South Korea.;Medical Research Center, Genomic Medicine Institute, Seoul National University College of Medicine, Seoul, 03080, South Korea.;Cancer Research Institute, Seoul National University, Seoul, 03080, South Korea. ^[8]

关键词 N6‐methyladenosine YTHDF proteins cancer immunity gastric cancer interferon‐γ signaling

主题词胃肿瘤(Stomach Neoplasms);小鼠(Mice);RNA结合蛋白质类(RNA-Binding Proteins);动物(Animals);人类(Humans);干扰素γ(Interferon-gamma);信号传导(Signal Transduction);减量调节(Down-Regulation);腺苷(Adenosine);细胞系, 肿瘤(Cell Line, Tumor);疾病模型, 动物(Disease Models, Animal);干扰素调节因子1(Interferon Regulatory Factor-1);男(雄)性(Male);女(雌)性(Female)

DOI 10.1002/advs.202410806

PMID 39587835

发布时间 2025-01-22

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025年12卷3期

e2410806页

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RNA N<sup>6</sup>-Methyladenosine-Binding Protein YTHDFs Redundantly Attenuate Cancer Immunity by Downregulating IFN-γ Signaling in Gastric Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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RNA N<sup>6</sup>-Methyladenosine-Binding Protein YTHDFs Redundantly Attenuate Cancer Immunity by Downregulating IFN-γ Signaling in Gastric Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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