Apolipoprotein E Induces Lipid Accumulation Through Dgat2 That Is Prevented with Time-Restricted Feeding in <i>Drosophila</i>.

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第一作者： Ruan C M,Moraes

第一单位： Department of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.;Department of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

作者： Ruan C M,Moraes ^[1] ; Jonathan R,Roth ^[2] ; Hailey,Mao ^[3] ; Savannah R,Crawley ^[3] ; Brittney P,Xu ^[3] ; John C,Watson ^[3] ; Girish C,Melkani ^[4]

作者单位： Department of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.;Department of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ^[1] Department of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.;Department of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ^[2] Department of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ^[3] Department of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.;UAB Nathan Shock Center, 1300 University Boulevard, Birmingham, AL 35294, USA. ^[4]

关键词 Alzheimer’s disease (AD)ApoE-alleles apolipoprotein E (ApoE)diacylglycerol O-acyltransferase 2 (Dgat2)drosophila model lipid metabolism time-restricted feeding (TRF)