Manipulation of Lipid Nanocapsules as an Efficient Intranasal Platform for Brain Deposition of Clozapine as an Antipsychotic Drug.

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作者： Ahmed A,Katamesh ^[1] ; Hend Mohamed,Abdel-Bar ^[2] ; Mohammed Khaled Bin,Break ^[3] ; Shimaa M,Hassoun ^[4] ; Gehad,Subaiea ^[5] ; Amr,Radwan ^[6] ; Hadel A,Abo El-Enin ^[7]

作者单位： Department of Pharmaceutics, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.;Department of Pharmaceutics, Egyptian Drug Authority, Giza 12511, Egypt. ^[1] Department of Pharmaceutics, Faculty of Pharmacy, University of Sadat City, Sadat City 32897, Egypt. ^[2] Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.;Medical and Diagnostic Research Centre, University of Ha'il, Ha'il 55473, Saudi Arabia. ^[3] Department of Pharmacology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia.;Northeast Delta Branch, Department of Pharmacies, Health Insurance Organization, Mansoura 35511, Egypt. ^[4] Department of Pharmacology, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia. ^[5] Research Department, Academy of Scientific Research and Technology, Cairo 11694, Egypt.;Egyptian Center for Innovation and Technology Development, Cairo 11512, Egypt. ^[6] Department of Pharmaceutics, Egyptian Drug Authority, Giza 12511, Egypt. ^[7]

关键词 Intranasal antipsychotic brain targeting clozapine lipid nanocapsule

DOI 10.3390/pharmaceutics16111417

PMID 39598541

发布时间 2024-11-30

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