首页> Respiratory research> Inhibition of IRE1α/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway.

Inhibition of IRE1α/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway.

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第一作者： Sijiao,Wang

第一单位： Department of Respiratory and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China.

作者： Sijiao,Wang ^[1] ; Lijuan,Hu ^[1] ; Yipeng,Fu ^[2] ; Fan,Xu ^[3] ; Yue,Shen ^[1] ; Hanhan,Liu ^[4] ; Lei,Zhu ^[5]

作者单位： Department of Respiratory and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, P.R. China. ^[1] Breast Surgery, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, China. ^[2] Department of Intensive Care Unit, Peoples Hospital of Peking University, Beijing, 100044, China. ^[3] Department of Respiratory and Critical Care Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China. lhhssym@163.com. ^[4] Department of Respiratory and Critical Care Medicine, Department of Respiratory and Critical Care Medicine, Huadong Hospital, Fudan University, Shanghai, 200040, China. tfzhu@126.com. ^[5]

关键词 Acute lung injury ERK/p65 IRE1α-XBP1 axis Inflammation NRLP3