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GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors.

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第一作者： Arttu,Jolma

第一单位： Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.

作者： Arttu,Jolma ^[1] ; Aldo,Hernandez-Corchado ^[2] ; Ally W H,Yang ^[1] ; Ali,Fathi ^[3] ; Kaitlin U,Laverty ^[4] ; Alexander,Brechalov ^[1] ; Rozita,Razavi ^[1] ; Mihai,Albu ^[1] ; Hong,Zheng ^[1] ; Codebook Consortium ^[5] ; Ivan V,Kulakovskiy ^[2] ; Hamed S,Najafabadi ^[6] ; Timothy R,Hughes

作者单位： Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada. ^[1] Department of Human Genetics, McGill University, Montréal, QC H3A 0C7, Canada.;Victor P. Dahdaleh Institute of Genomic Medicine, Montréal, QC H3A 0G1, Canada. ^[2] Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. ^[3] Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.;Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[4] Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia and Institute of Protein Research, Russian Academy of Sciences, 142290, Pushchino, Russia.;Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991, Moscow, Russia. ^[5] Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.;Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. ^[6]

关键词 C2H2 C2H2 zinc finger ChIP-Seq Codebook DNA binding specificity GHT-SELEX Gene regulation HT-SELEX MAGIX Modular binding PWM Position weight matrix RCADEEM SELEX TF Transcription factor Transcription factor binding site

DOI 10.1101/2024.11.11.618478

PMID 39605368

发布时间 2025-11-09

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GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors.

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GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors.

bioRxiv

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bioRxiv

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