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Pan-Cancer Drug Sensitivity Prediction from Gene Expression using Deep Learning.

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第一作者： Beronica A,Ocasio

第一单位： Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.;Sylvester Comprehensive Cancer Center, University of Miami.;Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami.

作者： Beronica A,Ocasio ^[1] ; Jiaming,Hu ^[2] ; Vasileios,Stathias ^[3] ; Maria J,Martinez ^[3] ; Kerry L,Burnstein ^[3] ; Stephan C,Schürer ^[4]

作者单位： Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.;Sylvester Comprehensive Cancer Center, University of Miami.;Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami. ^[1] Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.;Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami. ^[2] Sylvester Comprehensive Cancer Center, University of Miami.;Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami. ^[3] Sylvester Comprehensive Cancer Center, University of Miami.;Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami.;Frost Institute for Data Science & Computing, University of Miami, Miami, FL 33136, USA. ^[4]

关键词 AI cancer informatics cell sensitivity deep learning drug development drug screening precision oncology targeted therapies transcriptional signatures

DOI 10.1101/2024.11.15.623715

PMID 39605429

发布时间 2024-12-13

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