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PrP turnover in vivo and the time to effect of prion disease therapeutics.

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第一作者： Taylor L,Corridon

第一单位： Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.

作者： Taylor L,Corridon ^[1] ; Jill,O'Moore ^[2] ; Yuan,Lian ^[1] ; Vanessa,Laversenne ^[1] ; Briana,Noble ^[3] ; Nikita G,Kamath ^[1] ; Fiona E,Serack ^[1] ; Abdul Basit,Shaikh ^[4] ; Brian,Erickson ^[5] ; Craig,Braun ^[5] ; Kenney,Lenz ^[6] ; Michael,Howard ^[6] ; Nathan,Chan ^[6] ; Andrew G,Reidenbach ^[1] ; Deborah E,Cabin ^[2] ; Sonia M,Vallabh ^[7] ; Andrea,Grindeland ^[2] ; Nina,Oberbeck ^[8] ; Hien T,Zhao ^[3] ; Eric Vallabh,Minikel ^[7]

作者单位： Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. ^[1] Weissman Hood Institute, Great Falls, MT, 59405, USA. ^[2] Ionis Pharmaceuticals, Carlsbad, CA, 92010, USA. ^[3] Charles River Laboratories, Worcester, MA, 01605, USA. ^[4] IQ Proteomics, Framingham, MA, 01702, USA. ^[5] Comparative Medicine, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. ^[6] Program in Brain Health, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.;McCance Center for Brain Health and Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.;Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA.;Prion Alliance, Cambridge, MA, 02139, USA. ^[7] Gate Bio, Brisbane, CA, 94005, USA. ^[8]

DOI 10.1101/2024.11.12.623215

PMID 39605733

发布时间 2024-12-09

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