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Human CFTR deficient iPSC-macrophages reveal impaired functional and transcriptomic response upon <i>Pseudomonas aeruginosa</i> infection.

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作者单位: Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. [1] Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.;Paris Cité University, Imagine Institute, Paris, France.;Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.;Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States.;Broad Institute of MIT and Harvard, Cambridge, MA, United States. [2] Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, Hannover, Germany.;Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, Hannover, Germany.;REBIRTH, Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany. [3] Department of Medical Bioinformatics, University Medical Center Göttingen, Göttingen, Germany. [4] Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.;Paris Cité University, Imagine Institute, Paris, France. [5] Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, Hannover, Germany.;Research Core Unit Electron Microscopy, Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. [6] Colzyx AB, Lund, Sweden. [7] Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.;Paris Cité University, Imagine Institute, Paris, France.;Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris AP-HP, Paris, France.;St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, United States. [8] Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.;Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, Hannover, Germany. [9] Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.;Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover Medical School, Hannover, Germany.;REBIRTH, Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.;Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.;Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany. [10]
DOI 10.3389/fimmu.2024.1397886
PMID 39606224
发布时间 2024-11-30
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