Recombinant RAGE antagonist peptide promotes alveolar epithelial cell regeneration via the RAGE/MAPKs/MMP2 pathway in emphysema.

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作者： Jimin,Jang ^[1] ; Jooyeon,Lee ^[1] ; Jaehyun,Park ^[1] ; Sangryul,Cha ^[1] ; Se Bi,Lee ^[1] ; Sung-Min,Park ^[1] ; Seok-Ho,Hong ^[2] ; Woo Jin,Kim ^[2] ; Minhyung,Lee ^[3] ; Se-Ran,Yang ^[4]

作者单位： Department of Thoracic and Cardiovascular Surgery, Kangwon National University, Chuncheon, Gangwon State 24341, Republic of Korea. ^[1] Department of Internal Medicine, Kangwon National University, Chuncheon, Gangwon State 24341, Republic of Korea. ^[2] Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea. ^[3] Department of Thoracic and Cardiovascular Surgery, Kangwon National University, Chuncheon, Gangwon State 24341, Republic of Korea; Institute of Medical Science, School of Medicine, Kangwon National University, Chuncheon, Gangwon State, South Korea. Electronic address: seran@kangwon.ac.kr. ^[4]

关键词 Alveolar epithelial COPD MMP Oxidative stress RAGE

主题词动物(Animals);人类(Humans);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);基质金属蛋白酶2(Matrix Metalloproteinase 2);男(雄)性(Male);小鼠, 基因敲除(Mice, Knockout);再生(Regeneration);MAP激酶信号系统(MAP Kinase Signaling System);肺气肿(Pulmonary Emphysema);重组蛋白质类(Recombinant Proteins);肽类(Peptides);气肿(Emphysema)

DOI 10.1016/j.bcp.2024.116668

PMID 39608502

发布时间 2024-12-12

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Biochemical pharmacology

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Recombinant RAGE antagonist peptide promotes alveolar epithelial cell regeneration via the RAGE/MAPKs/MMP2 pathway in emphysema.

Biochemical pharmacology

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Biochemical pharmacology

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Recombinant RAGE antagonist peptide promotes alveolar epithelial cell regeneration via the RAGE/MAPKs/MMP2 pathway in emphysema.

Biochemical pharmacology

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Biochemical pharmacology

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