MYBBP1A‑mediated IGFBP4 promoter methylation promotes epithelial‑mesenchymal transition and metastasis through activation of NOTCH pathway in liver cancer.
第一作者:
Yujing,Sun
第一单位:
Department of General Practice, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
作者:
医学主题词
人类(Humans);肝肿瘤(Liver Neoplasms);上皮-间质转化(Epithelial-Mesenchymal Transition);癌, 肝细胞(Carcinoma, Hepatocellular);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);信号传导(Signal Transduction);男(雄)性(Male);受体, Notch1(Receptor, Notch1);女(雌)性(Female);胰岛素样生长因子结合蛋白质4(Insulin-Like Growth Factor Binding Protein 4);DNA甲基化(DNA Methylation);启动区, 遗传(Promoter Regions, Genetic);小鼠(Mice);细胞系, 肿瘤(Cell Line, Tumor);动物(Animals);预后(Prognosis);中年人(Middle Aged);细胞运动(Cell Movement);RNA结合蛋白质类(RNA-Binding Proteins);DNA结合蛋白质类(DNA-Binding Proteins);肿瘤转移(Neoplasm Metastasis);淋巴转移(Lymphatic Metastasis);减量调节(Down-Regulation)
DOI
10.3892/ijo.2024.5710
PMID
39611481
发布时间
2024-12-17
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