Unveiling the Potential of Cyclin-Dependent Kinases 4 and 6 Inhibitors Beyond Progression in Hormone Receptor Positive/Human Epidermal Growth Factor Negative Advanced Breast Cancer - A Clinical Review.

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作者： Chiara,Benvenuti ^[1] ; Thomas,Grinda ^[2] ; Elie,Rassy ^[3] ; Julia,Dixon-Douglas ^[4] ; Joana M,Ribeiro ^[3] ; Alberto,Zambelli ^[5] ; Armando,Santoro ^[6] ; Barbara,Pistilli ^[7]

作者单位： Department of Medical Oncology, Gustave Roussy, 114 Rue Edouard Vaillant, 94800, Villejuif, France.;Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090, Pieve Emanuele, MI, Italy.;Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089, Rozzano, MI, Italy. ^[1] Department of Medical Oncology, Gustave Roussy, 114 Rue Edouard Vaillant, 94800, Villejuif, France.;Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA. ^[2] Department of Medical Oncology, Gustave Roussy, 114 Rue Edouard Vaillant, 94800, Villejuif, France. ^[3] Department of Medical Oncology, Gustave Roussy, 114 Rue Edouard Vaillant, 94800, Villejuif, France.;Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, 305 Grattan Street, Parkville, Melbourne, Victoria, Australia. ^[4] Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090, Pieve Emanuele, MI, Italy.;Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089, Rozzano, MI, Italy. ^[5] Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089, Rozzano, MI, Italy. ^[6] Department of Medical Oncology, Gustave Roussy, 114 Rue Edouard Vaillant, 94800, Villejuif, France. barbara.pistilli@gustaveroussy.fr. ^[7]

关键词 ESR1 mutation Biomarkers CDK4/6i maintenance Cyclin-dependent kinases 4 and 6 inhibitors Hormone receptor-positive breast cancer