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Alzheimer's disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway.

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第一作者: Kyonghwan,Choe
第一单位: Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences (FHML), Mental Health and Neuroscience Research Institute (MHeNs) and European Graduate School of Neuroscience (EURON), Maastricht University, Maastricht, 6211 LK, the Netherlands.
作者单位: Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences (FHML), Mental Health and Neuroscience Research Institute (MHeNs) and European Graduate School of Neuroscience (EURON), Maastricht University, Maastricht, 6211 LK, the Netherlands. [1] Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences (FHML), Mental Health and Neuroscience Research Institute (MHeNs) and European Graduate School of Neuroscience (EURON), Maastricht University, Maastricht, 6211 LK, the Netherlands.;Computational Biology Group, Centre for System Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg.;Biomedical Data science Group, Centre for System Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg. [2] Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences (FHML), Mental Health and Neuroscience Research Institute (MHeNs) and European Graduate School of Neuroscience (EURON), Maastricht University, Maastricht, 6211 LK, the Netherlands.;Pattern Recognition and Bioinformatics, Department of Intelligent Systems, Delft University of Technology, Delft, the Netherlands. [3] Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences (FHML), Mental Health and Neuroscience Research Institute (MHeNs) and European Graduate School of Neuroscience (EURON), Maastricht University, Maastricht, 6211 LK, the Netherlands.;University of Exeter Medical School, University of Exeter, Exeter, UK. [4] Department of Psychiatry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. [5] Medical Faculty, Central Institute of Mental Health, Mannheim/Heidelberg University, Heidelberg, Germany. [6] Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany.;Department of Genomics, Life & Brain Center, University of Bonn, 53127, Bonn, Germany.;Division of Medical Genetics, Department of Biomedicine, University Hospital, University of Basel, CH-4058, Basel, Switzerland. [7] Medical Faculty, Institute of General Practice, Heinrich Heine University Düsseldorf, Düsseldorf, 40225, Germany. [8] Institute of Social Medicine, Occupational Health and Public Health, Leipzig University, Leipzig, 04103, Germany. [9] Work Group Medical Statistics and IT-Infrastructure, Institute for General Practice, Hannover Medical School, Hannover, Germany. [10] Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [11] Department of Neurodegeneration and Gerontopsychiatry, University of Bonn, 53127, Bonn, Germany.;German Center for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany. [12] Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences (FHML), Mental Health and Neuroscience Research Institute (MHeNs) and European Graduate School of Neuroscience (EURON), Maastricht University, Maastricht, 6211 LK, the Netherlands.;L.J. Roberts Center for Alzheimer's Research, Banner Sun Health Research Institute, Sun City, AZ, USA.;Biodesign Institute, Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA. [13] Biodesign Institute, Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA. [14] Department of Neurodegeneration and Gerontopsychiatry, University of Bonn, 53127, Bonn, Germany.;German Center for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany.;Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, 50937, Germany.;Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.;Department of Psychiatry, and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA. [15] Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences (FHML), Mental Health and Neuroscience Research Institute (MHeNs) and European Graduate School of Neuroscience (EURON), Maastricht University, Maastricht, 6211 LK, the Netherlands.;Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands. [16] Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences (FHML), Mental Health and Neuroscience Research Institute (MHeNs) and European Graduate School of Neuroscience (EURON), Maastricht University, Maastricht, 6211 LK, the Netherlands. d.vandenhove@maastrichtuniversity.nl. [17]
DOI 10.1186/s13195-024-01623-4
PMID 39616392
发布时间 2024-12-03
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