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首页> Biochemical and biophysical research communications> PCSK9 promotes vascular neointimal hyperplasia through non-lipid regulation of vascular smooth muscle cell proliferation, migration, and autophagy.

PCSK9 promotes vascular neointimal hyperplasia through non-lipid regulation of vascular smooth muscle cell proliferation, migration, and autophagy.

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作者： Qian,Zhang ^[1] ; Mengdan,Miao ^[2] ; Shanhu,Cao ^[1] ; Da,Liu ^[1] ; Zelong,Cao ^[1] ; Xiaoyu,Bai ^[1] ; Yajuan,Yin ^[1] ; Sheng,Jin ^[3] ; Lihua,Dong ^[4] ; Mingqi,Zheng ^[5]

作者单位： Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei, China; Hebei Key Laboratory of Heart and Metabolism, Shijiazhuang, 050031, Hebei, China. ^[1] Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei, China; Hebei Key Laboratory of Heart and Metabolism, Shijiazhuang, 050031, Hebei, China; Department of Cardiology, Handan First Hospital, Handan, 056000, Hebei, China. ^[2] Department of Physiology, Hebei Medical University, 361 zhongshan Road, Shijiazhuang, 050017, China. ^[3] Department of Biochemistry and Molecular Biology, Hebei Medical University, 050017, Shijiazhuang, China. ^[4] Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei, China; Hebei Key Laboratory of Heart and Metabolism, Shijiazhuang, 050031, Hebei, China. Electronic address: mzheng@hebmu.edu.cn. ^[5]

关键词 Autophagy Evolocumab Neointimal hyperplasia PCSK9 Proliferation VSMC

主题词动物(Animals);自噬(Autophagy);细胞增殖(Cell Proliferation);肌, 平滑, 血管(Muscle, Smooth, Vascular);细胞运动(Cell Movement);新内膜(Neointima);小鼠(Mice);增生(Hyperplasia);男(雄)性(Male);小鼠, 基因敲除(Mice, Knockout);小鼠, 近交C57BL(Mice, Inbred C57BL);肌细胞, 平滑肌(Myocytes, Smooth Muscle);信号传导(Signal Transduction)

DOI 10.1016/j.bbrc.2024.151081

PMID 39632291

发布时间 2024-12-19

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Biochemical and biophysical research communications

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