首页> Expert opinion on drug delivery> <i>Hif-1α</i> ablation reduces the efficiency of NeuroD1 gene-based therapy and aggravates the brain damage following ischemic stroke.

<i>Hif-1α</i> ablation reduces the efficiency of NeuroD1 gene-based therapy and aggravates the brain damage following ischemic stroke.

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第一作者： Nashwa,Amin

第一单位： Center for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.;Department of Neurology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, China.;Department of Zoology, Faculty of Science, Aswan University, Aswan, Egypt.

作者： Nashwa,Amin ^[1] ; Fei,Wu ^[2] ; Bing-Xin,Zhao ^[3] ; Zongjie,Shi ^[3] ; Ahmed,Abdelsadik ^[4] ; Abuelhassan,Elshazly Younis ^[5] ; Irum,Naz Abbasi ^[2] ; Javaria,Sundus ^[2] ; Azhar,Badry Hussein ^[2] ; Yu,Geng ^[3] ; Marong,Fang ^[6]

作者单位： Center for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.;Department of Neurology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, China.;Department of Zoology, Faculty of Science, Aswan University, Aswan, Egypt. ^[1] Institute of System Medicine, Zhejiang University School of Medicine, Hangzhou, China. ^[2] Center for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. ^[3] Department of Zoology, Faculty of Science, Aswan University, Aswan, Egypt.;Laboratory of Immunometabolism, Aswan University, Aswan, Egypt. ^[4] Department of Zoology, Faculty of Science, Aswan University, Aswan, Egypt. ^[5] Department of Neurology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, China.;Institute of System Medicine, Zhejiang University School of Medicine, Hangzhou, China. ^[6]

关键词 AAV ET-1 Hif-1αflox/flox Ischemic stroke NeuroD1 astrocyte gene-based therapy nestin-cre