Extensive epigenomic dysregulation is a hallmark of homologous recombination deficiency in triple-negative breast cancer.

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作者： Youdinghuan,Chen ^[1] ; Lucas A,Salas ^[2] ; Jonathan D,Marotti ^[3] ; Nicole P,Jenkins ^[4] ; Chao,Cheng ^[5] ; Todd W,Miller ^[6] ; Arminja N,Kettenbach ^[4] ; Brock C,Christensen ^[7]

作者单位： Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA.;Department of Epidemiology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA.;Department of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA. ^[1] Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA.;Department of Epidemiology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA. ^[2] Department of Pathology and Laboratory Medicine, Dartmouth Medical Center, One Medical Center Drive, Lebanon, New Hampshire, USA. ^[3] Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA.;Department of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA. ^[4] Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA.;Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA. ^[5] Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA.;Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. ^[6] Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA.;Department of Epidemiology, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA.;Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, One Medical Center Drive, Lebanon, New Hampshire, USA. ^[7]

关键词 BRCAness breast cancer epigenetics homologous recombination deficiency triple‐negative breast cancer