Suppressing GDF15 enhances the chemotherapeutic effect of 5 FU on MSI-H CRC by regulating the ferroptosis pathway SLC7A11/GSH/GPX4.

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作者： Zhi Min,Huang Fu ^[1] ; Ming,Xiao ^[2] ; Hailun,Xie ^[2] ; Shuxian,Zhang ^[2] ; Tang,Yi ^[2] ; Qingshu,Li ^[2] ; Ming,Li ^[3] ; Yalan,Wang ^[4]

作者单位： Department of Pathology, Molecular Medicine and Cancer Research Center, Department of Clinical Pathololgy, Laboratory of Pathology Diagnostic Center, Chongqing Medical University, Chongqing, China.;Department of Pathology, The Second Hospital Affiliated to Third Military Medical University, XinQiao Hospital, Chongqing, China. ^[1] Department of Pathology, Molecular Medicine and Cancer Research Center, Department of Clinical Pathololgy, Laboratory of Pathology Diagnostic Center, Chongqing Medical University, Chongqing, China. ^[2] Department of Pathology, Molecular Medicine and Cancer Research Center, Department of Clinical Pathololgy, Laboratory of Pathology Diagnostic Center, Chongqing Medical University, Chongqing, China. 500309@hospital.cqmu.edu.cn. ^[3] Department of Pathology, Molecular Medicine and Cancer Research Center, Department of Clinical Pathololgy, Laboratory of Pathology Diagnostic Center, Chongqing Medical University, Chongqing, China. wangyalan@cqmu.edu.cn. ^[4]

关键词 Colorectal cancer Ferroptosis GDF15 Microsatellite instability high