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Semi-mechanistic population pharmacokinetic modeling of DZIF-10c, a neutralizing antibody against SARS-Cov-2: predicting systemic and lung exposure following inhaled and intravenous administration.

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第一作者： Sree,Kurup

第一单位： Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT, 06877, USA. sree.kurup@boehringer-ingelheim.com.

作者： Sree,Kurup ^[1] ; Nieves Velez,de Mendizabal ^[2] ; Stephan,Becker ^[3] ; Erica,Bolella ^[4] ; Dorothy,De Sousa ^[5] ; Gerd,Fätkenheuer ^[6] ; Henning,Gruell ^[7] ; Florian,Klein ^[8] ; Jakob J,Malin ^[6] ; Ulrike,Schmid ^[9] ; Julia,Korell ^[10]

作者单位： Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT, 06877, USA. sree.kurup@boehringer-ingelheim.com. ^[1] Metrum Research Group, Tariffville, CT, 06081, USA.;Gilead, Foster City, CA, 94404, USA. ^[2] Institute of Virology, Philipps University Marburg, 35043, Marburg, Germany.;German Center for Infection Research (DZIF), Partner Site Giessen-Marburg-Langen, 35043, Marburg, Germany. ^[3] Biotherapeutics Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 06877, USA. ^[4] Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT, 06877, USA. ^[5] Department of Internal Medicine 1, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.;German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50931, Cologne, Germany. ^[6] Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany. ^[7] German Center for Infection Research (DZIF), Partner Site Giessen-Marburg-Langen, 35043, Marburg, Germany.;German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50931, Cologne, Germany.;Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany. ^[8] Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach an der Riss, Germany. ^[9] Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT, 06877, USA.;Metrum Research Group, Tariffville, CT, 06081, USA. ^[10]

关键词 Allometric scaling Inhaled administration Monoclonal antibodies Pharmacokinetic model Population pharmacokinetics Semi-mechanistic