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Molecular insights into the activation mechanism of GPR156 in maintaining auditory function.

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作者: Xiangyu,Ma [1] ; Li-Nan,Chen [2] ; Menghui,Liao [1] ; Liyan,Zhang [1] ; Kun,Xi [3] ; Jiamin,Guo [1] ; Cangsong,Shen [4] ; Dan-Dan,Shen [2] ; Pengjun,Cai [5] ; Qingya,Shen [6] ; Jieyu,Qi [7] ; Huibing,Zhang [2] ; Shao-Kun,Zang [2] ; Ying-Jun,Dong [2] ; Luwei,Miao [2] ; Jiao,Qin [2] ; Su-Yu,Ji [2] ; Yue,Li [5] ; Jianfeng,Liu [8] ; Chunyou,Mao [9] ; Yan,Zhang [10] ; Renjie,Chai [11]
作者单位: State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China. [1] Department of Pharmacology and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.;Liangzhu Laboratory, Zhejiang University, Hangzhou, China. [2] Department of Pharmacology and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. [3] Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China.;Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China. [4] Analytical Research Center for Organic and Biological Molecules, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Media, Chinese Academy of Sciences, Shanghai, China. [5] Liangzhu Laboratory, Zhejiang University, Hangzhou, China. [6] State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.;Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China.;Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing, China. [7] Key Laboratory of Molecular Biophysics of MOE, International Research Center for Sensory Biology and Technology of MOST, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China. jfliu@mail.hust.edu.cn.;Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China. jfliu@mail.hust.edu.cn. [8] Center for Structural Pharmacology and Therapeutics Development, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. maochunyou@zju.edu.cn. [9] Department of Pharmacology and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. zhang_yan@zju.edu.cn.;Liangzhu Laboratory, Zhejiang University, Hangzhou, China. zhang_yan@zju.edu.cn.;Center for Structural Pharmacology and Therapeutics Development, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. zhang_yan@zju.edu.cn.;MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, Hangzhou, China. zhang_yan@zju.edu.cn. [10] State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China. renjiec@seu.edu.cn.;Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China. renjiec@seu.edu.cn.;Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing, China. renjiec@seu.edu.cn.;Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. renjiec@seu.edu.cn.;Southeast University Shenzhen Research Institute, Shenzhen, China. renjiec@seu.edu.cn. [11]
DOI 10.1038/s41467-024-54681-5
PMID 39638804
发布时间 2024-12-08
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