The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication.

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第一作者： Paul J,Baker

第一单位： Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

作者： Paul J,Baker ^[1] ; Andrea C,Bohrer ^[1] ; Ehydel,Castro ^[1] ; Eduardo P,Amaral ^[1] ; Maryonne,Snow-Smith ^[2] ; Flor,Torres-Juárez ^[1] ; Sydnee T,Gould ^[3] ; Artur T L,Queiroz ^[4] ; Eduardo R,Fukutani ^[4] ; Cassandra M,Jordan ^[1] ; Jaspal S,Khillan ^[5] ; Kyoungin,Cho ^[5] ; Daniel L,Barber ^[3] ; Bruno B,Andrade ^[4] ; Reed F,Johnson ^[6] ; Kerry L,Hilligan ^[7] ; Katrin D,Mayer-Barber ^[1]

作者单位： Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA. ^[1] Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.;Human Eosinophil Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20892, USA. ^[2] T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20892, USA. ^[3] Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Salvador, Bahia 41810-710, Brazil.;Laboratory of Clinical and Translational Research, Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia 40296-710, Brazil. ^[4] Mouse Genetics and Gene Modification Section, Comparative Medicine Branch, NIAID, NIH, Rockville, MD 20852, USA. ^[5] SCV2 Virology Core, Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892, USA. ^[6] Malaghan Institute of Medical Research, Wellington 6012, New Zealand. ^[7]

主题词动物(Animals);病毒复制(Virus Replication);肺(Lung);小鼠(Mice);免疫, 先天(Immunity, Innate);小鼠, 近交C57BL(Mice, Inbred C57BL);人类(Humans);女(雌)性(Female);炎症(Inflammation)

DOI 10.1126/sciimmunol.adp7951

PMID 39642242

发布时间 2024-12-06

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Science immunology

2024年9卷102期

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The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication.

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The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication.

Science immunology

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