Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons.

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作者： Valerie,Espinal Abreu ^[1] ; Rachel,Barnes ^[1] ; Vishnupriya,Borra ^[1] ; Jennifer,Schurdak ^[1] ; Diego,Perez-Tilve ^[2]

作者单位： Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, USA. ^[1] Pharmacology and Systems Physiology, College of Medicine, University of Cincinnati, USA. Electronic address: pereztdo@ucmail.uc.edu. ^[2]

关键词 Agrp neurons Chemogenetics Glucose tolerance Insulin resistance Sympathetic nervous system

主题词动物(Animals);小鼠(Mice);神经元(Neurons);刺鼠相关蛋白质(Agouti-Related Protein);信号传导(Signal Transduction);葡萄糖(Glucose);男(雄)性(Male);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);能量代谢(Energy Metabolism);小鼠, 近交C57BL(Mice, Inbred C57BL);内环境稳定(Homeostasis);小鼠, 转基因(Mice, Transgenic);摄食行为(Feeding Behavior);下丘脑(Hypothalamus);女(雌)性(Female)

DOI 10.1016/j.molmet.2024.102079

PMID 39643082

发布时间 2025-01-09

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Molecular metabolism

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Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons.

Molecular metabolism

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Molecular metabolism

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Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons.

Molecular metabolism

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Molecular metabolism

相关期刊

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