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Multivariate genetic of 2.2 million individuals demonstrate genetic influences on substance use disorders operate via behavioral disinhibition and substance-specific risk.

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第一作者： Holly E,Poore

第一单位： Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University.

作者： Holly E,Poore ^[1] ; Chris,Chatzinakos ^[2] ; Brittany,Leger ^[3] ; Jean,Gonzalez ^[4] ; Travis T,Mallard ^[5] ; Sandra,Sanchez-Roige ^[6] ; Fazil,Aliev ^[1] ; Alexander,Hatoum ^[7] ; COGA Collaborators ^[8] ; Irwin D,Waldman ^[4] ; Abraham A,Palmer ^[9] ; K Paige,Harden ^[1] ; Danielle M,Dick ^[2] ; Peter B,Barr

作者单位： Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University. ^[1] Department of Psychiatry and Behavioral Science, SUNY Downstate Health Sciences University. ^[2] Department of Psychiatry, University of California San Diego. ^[3] Department of Psychiatry, University of California San Diego.;Institute for Genomic Medicine, University of California San Diego. ^[4] Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital.;Department of Psychiatry, Harvard Medical School. ^[5] Department of Psychiatry, University of California San Diego.;Institute for Genomic Medicine, University of California San Diego.;Department of Medicine, Vanderbilt University Medical Center. ^[6] Department of Psychiatry, Washington University School of Medicine. ^[7] Department of Psychology, Emory University. ^[8] Department of Psychology, University of Texas at Austin.;Population Research Center, University of Texas at Austin. ^[9]

DOI 10.1101/2024.11.26.24318011

PMID 39649581

发布时间 2026-04-07

基金项目

R01 DA050721/DA/NIDA NIH HHS/United States P50 AA022537/AA/NIAAA NIH HHS/United States K02 AA018755/AA/NIAAA NIH HHS/United States R01 AA015416/AA/NIAAA NIH HHS/United States U10 AA008401/AA/NIAAA NIH HHS/United States

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Multivariate genetic of 2.2 million individuals demonstrate genetic influences on substance use disorders operate via behavioral disinhibition and substance-specific risk.

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Multivariate genetic of 2.2 million individuals demonstrate genetic influences on substance use disorders operate via behavioral disinhibition and substance-specific risk.

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