换一批
换一批A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.
作者：
Stanley C,Xie [1]
;
Chia-Wei,Tai [2]
;
Craig J,Morton [3]
;
Liting,Ma [4]
;
Shih-Chung,Huang [4]
;
Sergio,Wittlin [5]
;
Yawei,Du [2]
;
Yongbo,Hu [4]
;
Con,Dogovski [2]
;
Mina,Salimimarand [6]
;
Robert,Griffin [4]
;
Dylan,England [4]
;
Elisa,de la Cruz [4]
;
Ioanna,Deni [7]
;
Tomas,Yeo [7]
;
Anna Y,Burkhard [7]
;
Josefine,Striepen [7]
;
Kyra A,Schindler [7]
;
Benigno,Crespo [8]
;
Francisco J,Gamo [8]
;
Yogesh,Khandokar [9]
;
Craig A,Hutton [6]
;
Tayla,Rabie [10]
;
Lyn-Marié,Birkholtz [10]
;
Mufuliat T,Famodimu [11]
;
Michael J,Delves [11]
;
Judith,Bolsher [12]
;
Karin M J,Koolen [12]
;
Rianne,van der Laak [12]
;
Anna C C,Aguiar [13]
;
Dhelio B,Pereira [14]
;
Rafael V C,Guido [15]
;
Darren J,Creek [16]
;
David A,Fidock [17]
;
Lawrence R,Dick [18]
;
Stephen L,Brand [19]
;
Alexandra E,Gould [20]
;
Steven,Langston [4]
;
Michael D W,Griffin [2]
;
Leann,Tilley [2]
作者单位：
Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.;Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
[1]
Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.
[2]
Biomedical Manufacturing Program, CSIRO, Clayton South, Victoria, Australia.
[3]
Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America.
[4]
Swiss Tropical and Public Health Institute, Allschwil, Switzerland.;University of Basel, Basel, Switzerland.
[5]
School of Chemistry, The University of Melbourne, Melbourne, Victoria, Australia.
[6]
Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, New York, United States of America.;Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America.
[7]
Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain.
[8]
ANSTO-Australian Synchrotron, Clayton, Victoria, Australia.
[9]
Department of Biochemistry, Genetics and Microbiology, University of Pretoria Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, South Africa.
[10]
Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
[11]
TropIQ Health Sciences, Nijmegen, The Netherlands.
[12]
Federal University of São Paulo, São Paulo, São Paulo, Brazil.
[13]
Research Center for Tropical Medicine of Rondonia, Porto Velho, Brazil.
[14]
Sao Carlos Institute of Physics, University of São Paulo, São Carlos, Brazil.
[15]
Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
[16]
Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, New York, United States of America.;Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America.;Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, United States of America.
[17]
Seofon Consulting, Natick, Massachusetts, United States of America.
[18]
Medicines for Malaria Venture, Geneva, Switzerland.
[19]
Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States of America.;Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
[20]
主题词
恶性疟原虫(Plasmodium falciparum);动物(Animals);小鼠(Mice);人类(Humans);疟疾, 恶性(Malaria, Falciparum);抗疟药(Antimalarials);酪氨酸tRNA连接酶(Tyrosine-tRNA Ligase);小鼠, SCID(Mice, SCID);投药, 口服(Administration, Oral);原虫蛋白质类(Protozoan Proteins);酶抑制剂(Enzyme Inhibitors);嘧啶类(Pyrimidines)
DOI
10.1371/journal.ppat.1012429
PMID
39652589
发布时间
2025-01-04
- 浏览0
PLoS pathogens
PLoS pathogens
e1012429页
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