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Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity.

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作者单位: Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.;Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-Ku, Japan. [1] Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.;Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan. [2] Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-Ku, Japan. [3] Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. [4] Division of Stem Cell and Molecular Medicine, Centre for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. [5] Department of Pathology, The Institute of Medical Science Research Hospital, University of Tokyo, Tokyo, Japan. [6] Division of Molecular Oncology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan. [7] Project for Personalized Cancer Medicine, Cancer Precision Medicine Centre, Japanese Foundation for Cancer Research, Tokyo, Japan. [8] The Institute of Laboratory Animals, Tokyo Women's Medical University, Tokyo, Japan. [9] Department of Microbiology and Immunology, Division of Infectious Genetics, University of Tokyo, Tokyo, Japan. [10] Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, Ibaraki, Japan. [11] Department of Hematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. [12] Rigel Pharmaceuticals, Inc., South San Francisco, CA, USA. [13] Research Platform Office, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. [14] Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. kitamura@ims.u-tokyo.ac.jp.;Molecular Pharmacology of Malignant Diseases, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-Ku, Japan. kitamura@ims.u-tokyo.ac.jp.;Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Japan. kitamura@ims.u-tokyo.ac.jp. [15]
DOI 10.1038/s44161-024-00579-w
PMID 39653824
发布时间 2024-12-12
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Nature cardiovascular research

Nature cardiovascular research

2024年3卷12期

1568-1583页

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