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Lurbinectedin sensitizes PD-L1 blockade therapy by activating STING-IFN signaling in small-cell lung cancer.

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第一作者： Subhamoy,Chakraborty

第一单位： Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

作者： Subhamoy,Chakraborty ^[1] ; Utsav,Sen ^[1] ; Kedwin,Ventura ^[1] ; Vrinda,Jethalia ^[2] ; Charles,Coleman ^[2] ; Subhasree,Sridhar ^[3] ; Avisek,Banerjee ^[1] ; Hilal,Ozakinci ^[4] ; Yazhini,Mahendravarman ^[1] ; Konrad,Snioch ^[1] ; Elisa,de Stanchina ^[5] ; Misty D,Shields ^[6] ; Lewis E,Tomalin ^[7] ; Deniz,Demircioglu ^[8] ; Theresa A,Boyle ^[9] ; Anna,Tocheva ^[3] ; Dan,Hasson ^[8] ; Triparna,Sen ^[10]

作者单位： Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[1] Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Bioinformatics for Next Generation Sequencing (BiNGS) core, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[2] Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[3] Department of Thoracic Oncology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL 33612, USA. ^[4] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[5] Division of Hematology/Oncology, Thoracic Oncology, IU School of Medicine, IU Health Physicians, Indianapolis, IN 46202, USA. ^[6] Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Bioinformatics for Next Generation Sequencing (BiNGS) core, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[7] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Bioinformatics for Next Generation Sequencing (BiNGS) core, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[8] Department of Pathology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL 33612, USA. ^[9] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: triparna.sen@mssm.edu. ^[10]

关键词 MHC-I PD-L1 blockade cGAS-STING immune activation small-cell lung cancer