Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening.

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作者： Matteo,Gentili ^[1] ; Rebecca J,Carlson ^[2] ; Bingxu,Liu ^[1] ; Quentin,Hellier ^[1] ; Jocelyn,Andrews ^[1] ; Yue,Qin ^[1] ; Paul C,Blainey ^[3] ; Nir,Hacohen ^[4]

作者单位： Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[1] Broad Institute of MIT and Harvard, Cambridge, MA, USA; Massachusetts Institute of Technology, Department of Health Sciences and Technology, Cambridge, MA, USA. ^[2] Massachusetts Institute of Technology, Department of Health Sciences and Technology, Cambridge, MA, USA; Massachusetts Institute of Technology, Department of Biological Engineering, Cambridge, MA, USA; Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA. Electronic address: pblainey@broadinstitute.org. ^[3] Massachusetts Institute of Technology, Department of Health Sciences and Technology, Cambridge, MA, USA; Massachusetts General Hospital, Krantz Family Center for Cancer Research, Boston, MA, USA. Electronic address: nhacohen@broadinstitute.org. ^[4]

关键词 DNA sensing STING STING trafficking functional genomics genome-wide CRISPR screen innate immunity optical pooled screen

主题词膜蛋白质类(Membrane Proteins);人类(Humans);蛋白质转运(Protein Transport);高尔基体(Golgi Apparatus);信号传导(Signal Transduction);内质网(Endoplasmic Reticulum);全基因组关联研究(Genome-Wide Association Study);动物(Animals)

DOI 10.1016/j.cels.2024.11.004

PMID 39657680

发布时间 2024-12-20

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Cell systems

2024年15卷12期

1264-1277.e8页

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Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening.

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Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening.

Cell systems

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Cell systems

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