换一批
换一批Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma.
作者：
Aristeidis,Papargyriou [1]
;
Mulham,Najajreh [2]
;
David P,Cook [3]
;
Carlo H,Maurer [4]
;
Stefanie,Bärthel [5]
;
Hendrik A,Messal [6]
;
Sakthi K,Ravichandran [2]
;
Till,Richter [7]
;
Moritz,Knolle [8]
;
Thomas,Metzler [9]
;
Akul R,Shastri [10]
;
Rupert,Öllinger [11]
;
Jacob,Jasper [2]
;
Laura,Schmidleitner [10]
;
Surui,Wang [12]
;
Christian,Schneeweis [5]
;
Hellen,Ishikawa-Ankerhold [13]
;
Thomas,Engleitner [11]
;
Laura,Mataite [2]
;
Mariia,Semina [14]
;
Hussein,Trabulssi [14]
;
Sebastian,Lange [15]
;
Aashreya,Ravichandra [10]
;
Maximilian,Schuster [2]
;
Sebastian,Mueller [11]
;
Katja,Peschke [2]
;
Arlett,Schäfer [2]
;
Sophie,Dobiasch [16]
;
Stephanie E,Combs [16]
;
Roland M,Schmid [17]
;
Andreas R,Bausch [18]
;
Rickmer,Braren [14]
;
Irina,Heid [14]
;
Christina H,Scheel [19]
;
Günter,Schneider [20]
;
Anja,Zeigerer [21]
;
Malte D,Luecken [22]
;
Katja,Steiger [9]
;
Georgios,Kaissis [23]
;
Jacco,van Rheenen [6]
;
Fabian J,Theis [24]
;
Dieter,Saur [5]
;
Roland,Rad [11]
;
Maximilian,Reichert [25]
作者单位：
Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.;Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.;Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.;Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.;Bavarian Cancer Research Center (BZKF), Munich, Germany.;Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.
[1]
Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.;Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.;Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.;Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.
[2]
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.;Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
[3]
Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.;Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.
[4]
Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.;Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.;Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
[5]
Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
[6]
Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.;Department of Mathematics, School of Computing, Information and Technology, Technical University of Munich, Munich, Germany.
[7]
Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany.;Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.
[8]
Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Munich, Germany.
[9]
Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.;Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.;Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.;Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.;Bavarian Cancer Research Center (BZKF), Munich, Germany.
[10]
Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.;Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.
[11]
Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany.;Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University, Heidelberg, Germany.;German Center for Diabetes Research (DZD), Neuherberg, Germany.
[12]
Department of Medicine I, University Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
[13]
Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany.
[14]
Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.;Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.;Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.
[15]
Department of Radiation Oncology, Technical University of Munich, Munich, Germany.;Institute of Radiation Medicine (IRM), Helmholtz Zentrum München, Neuherberg, Germany.
[16]
Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany.;Bavarian Cancer Research Center (BZKF), Munich, Germany.
[17]
Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany.;Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany.;Lehrstuhl für Zell Biophysik E27, Physik Department, Technische Universität München, Garching, Germany.
[18]
Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.;Department of Dermatology, Ruhr-University Bochum, Bochum, Germany.
[19]
Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.
[20]
Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany.;Joint Heidelberg-IDC Translational Diabetes Program, Heidelberg University, Heidelberg, Germany.;German Center for Diabetes Research (DZD), Neuherberg, Germany.;European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
[21]
Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.;Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), München, Germany.
[22]
Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Munich, Germany.;Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.;Institute for Machine Learning in Biomedical Imaging, Helmholtz Zentrum München, München, Germany.;Department of Computing, Imperial College London, London, UK.;Munich Center for Machine Learning (MCML), München, Germany.;School of Computation, Information and Technology, Technische Universität München, München, Germany.
[23]
Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany.;Department of Mathematics, School of Computing, Information and Technology, Technical University of Munich, Munich, Germany.;Cellular Genetics Programme, Wellcome Sanger Institute, Hinxton, Cambridge, UK.
[24]
Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany. maximilian.reichert@tum.de.;Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, München, Germany. maximilian.reichert@tum.de.;Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany. maximilian.reichert@tum.de.;Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany. maximilian.reichert@tum.de.;Bavarian Cancer Research Center (BZKF), Munich, Germany. maximilian.reichert@tum.de.;German Cancer Consortium (DKTK), partner site Munich, Munich, Germany. maximilian.reichert@tum.de.;Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Munich, Germany. maximilian.reichert@tum.de.
[25]
DOI
10.1038/s41551-024-01273-9
PMID
39658630
发布时间
2024-12-10
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Nature biomedical engineering
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