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Transcriptome and epigenome dynamics of the clonal heterogeneity of human induced pluripotent stem cells for cardiac differentiation.

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第一作者： Jihye,Yun

第一单位： Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea.;School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

作者： Jihye,Yun ^[1] ; Jaemin,So ^[1] ; Seunghee,Jeong ^[1] ; Jiye,Jang ^[1] ; Soyoung,Han ^[1] ; Junseok,Jeon ^[2] ; Kyungho,Lee ^[2] ; Hye Ryoun,Jang ^[2] ; Jaecheol,Lee ^[3]

作者单位： Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea.;School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. ^[1] Division of Nephrology, Department of Medicine, Cell and Gene Therapy Institute, Samsung Medical Center, Sungkyunkwan University of Medicine, Seoul, Republic of Korea. ^[2] Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea. jaecheol@skku.edu.;School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. jaecheol@skku.edu.;Epigenome Dynamics Control Research Center (EDCRC), School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. jaecheol@skku.edu.;Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea. jaecheol@skku.edu. ^[3]

关键词 Cardiomyocyte differentiation efficiency Clonal variation Induced pluripotent stem cells Integrative analysis Predictive biomarker

医学主题词人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);细胞分化(Cell Differentiation);肌细胞, 心脏(Myocytes, Cardiac);细胞, 培养的(Cells, Cultured);染色质(Chromatin)

DOI 10.1007/s00018-024-05493-9

PMID 39661125

发布时间 2024-12-14

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