Mapping functional elements of the DNA damage response through base editor screens.

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作者： Qian,Pan ^[1] ; Zhixuan,Zhang ^[1] ; Yangfang,Xiong ^[1] ; Ying,Bao ^[2] ; Tianxin,Chen ^[1] ; Ping,Xu ^[1] ; Zhiheng,Liu ^[1] ; Huazheng,Ma ^[1] ; Ying,Yu ^[1] ; Zhuo,Zhou ^[3] ; Wensheng,Wei ^[4]

作者单位： Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China. ^[1] Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China; Changping Laboratory, Beijing 102206, China. ^[2] Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China; State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China. ^[3] Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China; Changping Laboratory, Beijing 102206, China. Electronic address: wswei@pku.edu.cn. ^[4]

关键词 CP: Molecular biology CRISPR screen DNA damage response base editing screen functional genomics lysine residue

主题词 DNA损伤(DNA Damage);人类(Humans);DNA修复(DNA Repair);顺铂(Cisplatin);突变(Mutation);复制蛋白A(Replication Protein A);HEK293细胞(HEK293 Cells)

DOI 10.1016/j.celrep.2024.115047

PMID 39661519

发布时间 2024-12-26

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