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Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial.

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第一作者: Icro,Meattini
第一单位: Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. Electronic address: icro.meattini@unifi.it.
作者单位: Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. Electronic address: icro.meattini@unifi.it. [1] Radiation Oncology, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy. [2] Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. [3] Department of Radiotherapy and Radiosurgery, Istituto Clinico Humanitas - Humanitas Cancer Center, Milan, Italy. [4] Radiation Oncology Department, IRCCS Ospedale Policlinico San Martino, Genova, Italy. [5] Department of Radiation Oncology, University Hospital of Modena, Modena, Italy. [6] Department of Radiation Oncology, Santa Chiara Hospital, Trento, Italy. [7] Department of Radiation Oncology, IRCCS San Matteo Polyclinic Foundation, Pavia, Italy. [8] Department of Radiation Oncology, "Santa Maria della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. [9] UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy. [10] Oncology and Hematology Department, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy. [11] Department of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital, Göteborg, Sweden. [12] Paris Sciences and Lettres University, Paris, France; Institut Curie, Hopital René Huguenin, Saint-Cloud, France. [13] Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. [14] Department of Geriatric Medicine, Diakonessenhuis Utrecht, Utrecht, Netherlands. [15] Breast Cancer Radiation Therapy Unit, Sheba Medical Center, Ramat Gan, Israel; The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; GROW-School for Oncology and Reproduction (Maastro), Maastricht University, Maastricht, Netherlands. [16] Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Genova, Italy; Department of Medical Oncology, UOC Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy. [17] Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy; Medical Physics Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. [18] Europa Donna, European Breast Cancer Coalition, Milan, Italy; Europa Donna Slovenia, Ljubljana, Slovenia. [19] Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. [20] Sussex Health Outcomes Research & Education in Cancer (SHORE-C), Brighton & Sussex Medical School, University of Sussex, Brighton, East Sussex, UK. [21] Department of Radiation Oncology, Iridium Netwerk, Wilrijk-Antwerp, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk-Antwerp, Belgium. [22] Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. [23]
DOI 10.1016/S1470-2045(24)00661-2
PMID 39675376
发布时间 2025-01-14
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