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Pathobiont-driven antibody sialylation through IL-10 undermines vaccination.

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第一作者： Chih-Ming,Tsai

第一单位： Division of Infectious Diseases, Department of Pediatrics, University of California, La Jolla, California, USA.

作者： Chih-Ming,Tsai ^[1] ; Irshad A,Hajam ^[1] ; J R,Caldera ^[1] ; Austin Wt,Chiang ^[2] ; Cesia,Gonzalez ^[1] ; Xin,Du ^[1] ; Biswa,Choudhruy ^[3] ; Haining,Li ^[4] ; Emi,Suzuki ^[5] ; Fatemeh,Askarian ^[6] ; Ty'Tianna,Clark ^[7] ; Brian,Lin ^[1] ; Igor H,Wierzbicki ^[8] ; Angelica M,Riestra ^[7] ; Douglas J,Conrad ^[9] ; David J,Gonzalez ^[8] ; Victor,Nizet ^[10] ; Nathan E,Lewis ^[11] ; George Y,Liu ^[12]

作者单位： Division of Infectious Diseases, Department of Pediatrics, University of California, La Jolla, California, USA. ^[1] Immunology Center of Georgia and Department of Medicine, Augusta University, Augusta, Georgia, USA. ^[2] Glycobiology Research and Training Center, UCSD, La Jolla, California, USA. ^[3] Department of Bioengineering, University of California, La Jolla, California, USA. ^[4] Division of Gastroenterology, Department of Pediatrics, UCSD, La Jolla, California, USA.;Division of Gastroenterology, Rady Children's Hospital, San Diego, California, USA. ^[5] Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego School of Medicine, La Jolla, California, USA. ^[6] Department of Biology, San Diego State University, San Diego, California, USA. ^[7] Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, California, USA. ^[8] Division of Pulmonary, Critical Care and Sleep Medicine, UCSD, La Jolla, California, USA. ^[9] Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego School of Medicine, La Jolla, California, USA.;Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, La Jolla, California, USA. ^[10] Department of Bioengineering, University of California, La Jolla, California, USA.;Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego School of Medicine, La Jolla, California, USA. ^[11] Division of Infectious Diseases, Department of Pediatrics, University of California, La Jolla, California, USA.;Division of Infectious Diseases, Rady Children's Hospital, San Diego, California, USA. ^[12]

关键词 Adaptive immunity Immunology Imprinting Infectious disease

医学主题词白细胞介素10(Interleukin-10);动物(Animals);小鼠(Mice);金黄色葡萄球菌(Staphylococcus aureus);人类(Humans);抗体, 细菌(Antibodies, Bacterial);唾液酸转移酶类(Sialyltransferases);葡萄球菌菌苗(Staphylococcal Vaccines);接种(Vaccination);STAT3转录因子(STAT3 Transcription Factor);女(雌)性(Female);糖基化(Glycosylation);B-淋巴细胞(B-Lymphocytes);葡萄球菌感染(Staphylococcal Infections)

DOI 10.1172/JCI179563

PMID 39680460

发布时间 2026-03-07

基金项目

R01 AI144694/AI/NIAID NIH HHS/United States R01 AI179098/AI/NIAID NIH HHS/United States R01 AI181321/AI/NIAID NIH HHS/United States R35 GM119850/GM/NIGMS NIH HHS/United States R01 AI127406/AI/NIAID NIH HHS/United States

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