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Schwann Cell-Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice.

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第一作者： Lisa,Gambarotto

第一单位： Department of Molecular Medicine, University of Padova, Via U. Bassi 58/B, Padova, 35131, Italy.;Department of Biology, University of Padova, Via U. Bassi 58/B, Padova, 35131, Italy.

作者： Lisa,Gambarotto ^[1] ; Loris,Russo ^[2] ; Silvia,Bresolin ^[3] ; Luca,Persano ^[3] ; Rachele,D'Amore ^[2] ; Giulia,Ronchi ^[4] ; Federica,Zen ^[4] ; Luisa,Muratori ^[4] ; Alice,Cani ^[5] ; Samuele,Negro ^[6] ; Aram,Megighian ^[7] ; Sonia,Calabrò ^[1] ; Paola,Braghetta ^[2] ; Dario,Bizzotto ^[2] ; Matilde,Cescon ^[2]

作者单位： Department of Molecular Medicine, University of Padova, Via U. Bassi 58/B, Padova, 35131, Italy.;Department of Biology, University of Padova, Via U. Bassi 58/B, Padova, 35131, Italy. ^[1] Department of Molecular Medicine, University of Padova, Via U. Bassi 58/B, Padova, 35131, Italy. ^[2] Department of Women and Children's Health, University of Padova, via Giustiniani 3, Padova, 35127, Italy.;Istituto di Ricerca Pediatrica - Città della Speranza, Corso Stati Uniti 4, Padova, 35128, Italy. ^[3] Department of Clinical and Biological Sciences & Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Regione Gonzole 10, Orbassano, Torino, 10043, Italy. ^[4] Department of Women and Children's Health, University of Padova, via Giustiniani 3, Padova, 35127, Italy. ^[5] U.O.C. Clinica Neurologica, Azienda Ospedale-Università Padova, Via Giustiniani 5, Padova, 35128, Italy. ^[6] Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, Padova, 35131, Italy.;Padova Neuroscience Center, University of Padova, Via G. Orus, 2, Padova, 35131, Italy. ^[7]

关键词 Beclin 1 Schwann cells autophagy motor function myelination neuropathy sensory function

医学主题词动物(Animals);许旺细胞(Schwann Cells);小鼠(Mice);疾病模型, 动物(Disease Models, Animal);髓鞘(Myelin Sheath);小鼠, 基因敲除(Mice, Knockout);坐骨神经(Sciatic Nerve)

DOI 10.1002/advs.202308965

PMID 39680476

发布时间 2025-04-27

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