Diverse N-Oxidation of Primary Aromatic Amines Controlled by Engineered P450 Peroxizyme Variants Facilitated by Dual-Functional Small Molecule.

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第一作者： Jie,Chen

第一单位： Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao New Energy Shandong Laboratory, CAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.;University of Chinese Academy of Sciences, Beijing, 100049, China.

作者： Jie,Chen ^[1] ; Fuquan,Yao ^[2] ; Yiping,Jiang ^[2] ; Xiangquan,Qin ^[2] ; Mo,Xian ^[1] ; Yingang,Feng ^[1] ; Zhiqi,Cong ^[1]

作者单位： Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao New Energy Shandong Laboratory, CAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.;University of Chinese Academy of Sciences, Beijing, 100049, China. ^[1] Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao New Energy Shandong Laboratory, CAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China. ^[2]

关键词 N‐oxygenation amine cytochrome P450 enzymes enzyme catalysis one‐electron oxidation

主题词氧化还原(Oxidation-Reduction);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);胺类(Amines);蛋白质工程(Protein Engineering)

DOI 10.1002/advs.202412100

PMID 39680753

发布时间 2025-02-12

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2025年12卷6期

e2412100页

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Diverse N-Oxidation of Primary Aromatic Amines Controlled by Engineered P450 Peroxizyme Variants Facilitated by Dual-Functional Small Molecule.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Diverse N-Oxidation of Primary Aromatic Amines Controlled by Engineered P450 Peroxizyme Variants Facilitated by Dual-Functional Small Molecule.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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