Macrophage Inhibitor Clodronate Enhances Liver Transduction of Lentiviral but Not Adeno-Associated Viral Vectors or mRNA Lipid Nanoparticles in Neonatal and Juvenile Mice.

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第一作者： Loukia,Touramanidou

第一单位： Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, UK.

作者： Loukia,Touramanidou ^[1] ; Sonam,Gurung ^[1] ; Claudiu A,Cozmescu ^[1] ; Dany,Perocheau ^[1] ; Dale,Moulding ^[1] ; Patrick F,Finn ^[2] ; Andrea,Frassetto ^[2] ; Simon N,Waddington ^[3] ; Paul,Gissen ^[4] ; Julien,Baruteau ^[4]

作者单位： Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, UK. ^[1] Moderna, Inc., Cambridge, MA 02139, USA. ^[2] Institute for Women's Health, University College London, London WC1E 6HX, UK.;Wits/SAMRC Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of Witswatersrand, Johannesburg 2193, South Africa. ^[3] Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, UK.;Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK. ^[4]

关键词 AAV LNP mRNA LV expression gene therapy hepatocytes lentiviral vector liver macrophage inhibitors macrophages spleen transduction

主题词动物(Animals);依赖病毒(Dependovirus);遗传载体(Genetic Vectors);纳米粒子(Nanoparticles);肝(Liver);氯膦酸(Clodronic Acid);小鼠(Mice);RNA, 信使(RNA, Messenger);转导, 遗传(Transduction, Genetic);慢病毒属(Lentivirus);巨噬细胞(Macrophages);动物, 新生(Animals, Newborn);小鼠, 近交C57BL(Mice, Inbred C57BL);脂类(Lipids);肝细胞(Hepatocytes);脂质体(Liposomes)

DOI 10.3390/cells13231979

PMID 39682727

发布时间 2025-01-04

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2024年13卷23期

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Macrophage Inhibitor Clodronate Enhances Liver Transduction of Lentiviral but Not Adeno-Associated Viral Vectors or mRNA Lipid Nanoparticles in Neonatal and Juvenile Mice.

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Macrophage Inhibitor Clodronate Enhances Liver Transduction of Lentiviral but Not Adeno-Associated Viral Vectors or mRNA Lipid Nanoparticles in Neonatal and Juvenile Mice.

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