Conformation pattern changes in R1-pS262 tau peptide induced endogenous tau aggregation, synaptic damage, and cognitive impairments.

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第一作者： Gang,Wu

第一单位： School of Basic Medicine, Key Laboratory of Education Ministry/Hubei province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.;Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.

作者： Gang,Wu ^[1] ; Yong,Luo ^[1] ; Qian,Guo ^[2] ; Mingming,Yang ^[2] ; Yacoubou Abdoul Razak,Mahaman ^[3] ; Yi,Liu ^[2] ; Jian-Zhi,Wang ^[4] ; Rong,Liu ^[2] ; Xiang,Gao ^[5] ; Xiaochuan,Wang ^[4]

作者单位： School of Basic Medicine, Key Laboratory of Education Ministry/Hubei province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.;Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China. ^[1] School of Basic Medicine, Key Laboratory of Education Ministry/Hubei province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ^[2] Hubei Provincial Key Laboratory of Occurrence and Intervention of Kidney Diseases, Medical College, Hubei Polytechnic University, Huangshi, China. ^[3] School of Basic Medicine, Key Laboratory of Education Ministry/Hubei province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.;Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.;Hubei Key Laboratory of Cognitive and Affective Disorders, School of Medicine, Jianghan University, Wuhan, China. ^[4] Department of Pharmacy, Renmin Hospital, Wuhan University, Wuhan, China. ^[5]

关键词 Alzheimer's disease R1-pS262 phosphorylation protein folding shape code tau aggregation