首页> Cell reports> Longitudinal phosphoproteomics reveals the PI3K-PAK1 axis as a potential target for recurrent colorectal liver metastases.

Longitudinal phosphoproteomics reveals the PI3K-PAK1 axis as a potential target for recurrent colorectal liver metastases.

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第一作者： Daigo,Gunji

第一单位： Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

作者： Daigo,Gunji ^[1] ; Yuichi,Abe ^[2] ; Satoshi,Muraoka ^[3] ; Ryohei,Narumi ^[3] ; Junko,Isoyama ^[3] ; Narumi,Ikemoto ^[3] ; Mimiko,Ishida ^[3] ; Akina,Shinkura ^[1] ; Takeshi,Tomonaga ^[3] ; Satoshi,Nagayama ^[4] ; Yu,Takahashi ^[5] ; Yosuke,Fukunaga ^[5] ; Yoshiharu,Sakai ^[6] ; Kazutaka,Obama ^[6] ; Jun,Adachi ^[7]

作者单位： Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan. ^[1] Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Immunoproteomics Laboratory, Institute for Glyco-core Research (iGCORE), Gifu University, Gifu 501-1193, Japan. ^[2] Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan. ^[3] Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan; Department of Surgery, Uji-Tokusyukai Medical Center, Kyoto 611-0041, Japan. ^[4] Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan. ^[5] Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan. ^[6] Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory of Proteomics and Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan. Electronic address: jun_adachi@nibiohn.go.jp. ^[7]

关键词 CP: Cancer chemotherapy resistance colorectal cancer liver metastases computational approaches drug repositioning phosphoproteomic dynamics