The Progression-Free-Survival Ratio in Molecularly Aided Tumor Trials: A Critical Examination of Current Practice and Suggestions for Alternative Methods.

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第一作者： Dominic,Edelmann

第一单位： Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

作者： Dominic,Edelmann ^[1] ; Tobias,Terzer ^[1] ; Peter,Horak ^[2] ; Richard,Schlenk ^[3] ; Axel,Benner ^[1]

作者单位： Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[1] Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[2] Department of Internal Medicine V and Internal Medicine VI, Heidelberg University Hospital, Heidelberg, Germany.;NCT Trial Center, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany. ^[3]

关键词 Weibull distribution accelerated failure time model growth modulation index marginal model paired time‐to‐event data progression‐free‐survival ratio

主题词人类(Humans);生物测量学(Biometry);肿瘤(Neoplasms);临床试验(主题)(Clinical Trials as Topic);分子靶向治疗(Molecular Targeted Therapy);模型, 统计学(Models, Statistical);比例危险度模型(Proportional Hazards Models)

DOI 10.1002/bimj.70028

PMID 39692541

发布时间 2025-01-04

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