Structural commonalities determined by physicochemical principles in the complex polymorphism of the amyloid state of proteins.

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作者： Silvia,Errico ^[1] ; Giulia,Fani ^[1] ; Salvador,Ventura ^[2] ; Joost,Schymkowitz ^[3] ; Frederic,Rousseau ^[3] ; Antonio,Trovato ^[4] ; Michele,Vendruscolo ^[5] ; Francesco,Bemporad ^[1] ; Fabrizio,Chiti ^[1]

作者单位： Department of Experimental and Clinical Biomedical Sciences "Mario Serio", Section of Biochemistry, University of Florence, 50134 Florence, Italy. ^[1] Institut de Biotecnologia i de Biomedicina (IBB) and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. ^[2] Switch Laboratory, VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.;Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.;Switch Laboratory, VIB Center for AI & Computational Biology, 3000 Leuven, Belgium. ^[3] Department of Physics and Astronomy "G. Galilei", University of Padova, 35131 Padova, Italy.;National Institute of Nuclear Physics (INFN), Padova Section, University of Padova, 35131 Padova, Italy. ^[4] Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, CB21EW Cambridge, U.K. ^[5]

关键词 Aggregation hot spots Aggregation propensity profile Aggregation score Amyloid hot spots Amyloid prediction Amyloid predictors