Characterisation of the tumour microenvironment and PD-L1 granularity reveals the prognostic value of cancer-associated myofibroblasts in non-invasive bladder cancer.

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作者： Carmen G,Cañizo ^[1] ; Félix,Guerrero-Ramos ^[1] ; Mercedes,Perez Escavy ^[2] ; Iris,Lodewijk ^[2] ; Cristian,Suárez-Cabrera ^[2] ; Lucía,Morales ^[2] ; Sandra P,Nunes ^[3] ; Ester,Munera-Maravilla ^[2] ; Carolina,Rubio ^[2] ; Rebeca,Sánchez ^[4] ; Marta,Rodriguez-Izquierdo ^[1] ; Jaime,Martínez de Villarreal ^[5] ; Francisco X,Real ^[6] ; Daniel,Castellano ^[7] ; Cristina,Martín-Arriscado ^[8] ; David,Lora Pablos ^[8] ; Alfredo,Rodríguez Antolín ^[1] ; Marta,Dueñas ^[2] ; Jesús M,Paramio ^[2] ; Victor G,Martínez ^[2]

作者单位： Urology Department, University Hospital '12 de Octubre', Madrid, Spain. ^[1] Molecular and Translational Oncology Division, Biomedical Innovation Unit, CIEMAT, Madrid, Spain.;Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain.;Institute of Biomedical Research, University Hospital '12 de Octubre', Madrid, Spain. ^[2] Molecular and Translational Oncology Division, Biomedical Innovation Unit, CIEMAT, Madrid, Spain.;Institute of Biomedical Research, University Hospital '12 de Octubre', Madrid, Spain.;Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/CI-IPOP@RISE (Health Research Network) Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC), Porto, Portugal. ^[3] Cell Technology Division, Biomedical Innovation Unit, CIEMAT, Madrid, Spain.;Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER), Madrid, Spain. ^[4] Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain.;Epithelial Carcinogenesis Group, Spanish National Cancer Centre-CNIO, Madrid, Spain. ^[5] Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain.;Epithelial Carcinogenesis Group, Spanish National Cancer Centre-CNIO, Madrid, Spain.;Departament de Medicina i Ciències de la Vida, Universitat Pompeu Fabra, Barcelona, Spain. ^[6] Oncology Department, University Hospital '12 de Octubre', Madrid, Spain. ^[7] Scientific Support Unit, Research Institute I+12, University Hospital 12 de Octubre, Madrid, Spain. ^[8]

关键词 Bladder cancer Myofibroblasts PD-L1 cancer-associated fibroblasts tumor microenvironment