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A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer.

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第一作者: Jeremy B,Foote
第一单位: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama.
作者单位: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama. [1] University of South Alabama, Mobile, Alabama. [2] Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama.;ADT Pharmaceuticals LLC, Orange Beach, Alabama. [3] Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama. [4] Department of Gastroenterological Surgery, Oslo University Hospital, The Radium Hospital, Oslo, Norway.;Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. [5] Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama. [6] Department of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, Alabama. [7] University of South Alabama, Mobile, Alabama.;ADT Pharmaceuticals LLC, Orange Beach, Alabama. [8] Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama. [9] University of Connecticut, Mansfield, Connecticut. [10] Georgia Cancer Center, University of Augusta, Augusta, Georgia. [11] CellarisBio LLC, San Diego, California. [12] Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois. [13] ADT Pharmaceuticals LLC, Orange Beach, Alabama. [14] Department of Pharmaceutical, Social and Administrative Sciences, McWhorter School of Pharmacy, Samford University; Birmingham, Alabama. [15] Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama. [16] Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama. [17]
DOI 10.1158/0008-5472.CAN-24-0323
PMID 39700396
发布时间 2025-10-01
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